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In experiments of other receptor tyrosine kinases implicated in the oncogenesis of GIST, nilotinib achieved potent and selective inhibition of PDGFRα and PDGFRβ. As is the case with imatinib, nilotinib potently inhibited the autophosphorylation of A31 cells transformed by PDGFRAVancomycin was 1st isolated in 1953, by Edmund Kornfeld (Doing work a